Kipo and the Age of Wonderbeasts

Plot
Sometime by the 23rd century, animals have mutated to become anthropomorphic creatures known as "mutes". Most mutes rose up against their human oppressors, forcing the majority of the human race to live in underground cities called burrows, while civilization has been reduced to a post-apocalyptic wasteland collectively known as "Las Vistas".

In the first season, Kipo Oak, a thirteen-year-old girl, is separated from her father Lio after their burrow is attacked by a "mega monkey", a colossal, mutated spider monkey. Traversing through Las Vistas, she meets and befriends Wolf, a cold and hardened girl who has been surviving on her own after her adoptive wolf family turned on her, the upbeat Benson and his insect companion Dave, and the mute pig Mandu. Together, they set out to find the burrow Lio and the rest of Kipo's community fled to after their first one was destroyed. During their adventures, Kipo discovers that she has the DNA of a mega jaguar inside of her, and can partially transform her body. As the five journey along they make many mute allies and enemies, including the tyrant Scarlemagne, a mandrill mute who intends to subjugate humanity with his mind-controlling pheromones and force the other mutes into an utopian empire which he will rule with a human army.

In the second season, Kipo seeks to rescue her people after they are captured by Scarlemagne. Kipo learns she was experimented with mute DNA by her parents before her birth, turning her into a half-human, half-jaguar hybrid, and that that her mother Song, previously thought to be deceased, is actually the mega monkey who destroyed her burrow, mutated as a side effect from her pregnancy and mind-controlled with Scarlemagne's pheromones by the manipulative Dr. Emilia, her parents' former employer who now leads a resistance group against mutes. She also discovers that Scarlemagne was originally an ordinary mandrill named Hugo whom Kipo's parents turned sentient and secretly raised as their son, but grew to hate them after they were forced to abandon him. These revelations slowly cause Kipo to start to lose control of her abilities, putting her at risk of transforming into a mega jaguar permanently, but she is able to regain control with the help of her friends and family. She frees Song from her mind control and defeats Scarlemagne, but meanwhile Dr. Emilia has turned most of Kipo's people over to her cause of reverting mutes back into normal animals so human civilization can rise again.

In the third season, Kipo creates the "Human Mute Ultimate Friendship Alliance" (HMUFA) to thwart Dr. Emilia, but struggles to make humans and mutes work together. Emilia manages to create an anti-mute cure with Kipo's DNA, and it is with this cure that Kipo turns her mother human again. Ultimately, Kipo succeeds in making peace between mutes and humans. With her plans foiled and unwilling to accept change, Emilia turns herself into a mega mute to kill Kipo and her friends, but she is defeated with Scarlemagne's help, who sacrifices himself to save Kipo. Five years later, Kipo happily lives on the surface where humans and mutes finally co-exist in harmony.